New Advances in Cell Microarray Technology to Expand Applications in Target Deconvolution and Off-Target Screening

The Cancer Stem Cell Hypothesis in Oral Squamous Cell Carcinoma: A New Target for the Treatment

Within a single tumor clone, cells have significantly different abilities to proliferate and form new tumors. This has led to the hypothesis that most cells in a cancer have a limited ability to divide and only a small subset of distinct cells, the cancer stem cells (CSCs), has the capacity to self-renew and form new tumors . It has been proposed that the development of tumors is based exclusiv...

High content cellular microarray for automated drug target deconvolution

Despite the promising paradigm offered by high-content screening, the concrete execution of hundred of thousands of visual cell-based experiments has remained highly challenging in terms of both statistical robustness and speed. An efficient computational method for cellular microarrays was developed at Institut Pasteur-Korea that allow for high speed, high content genome-wide siRNA screening. ...

New ESC/EASD lipid guidelines empahsises need to expand cholesterol screening and treating to target in clinical practice.

‘Clinicians are not measuring cholesterol levels often enough in at-risk patients worldwide, and the new ESC/EAS (European Society of Cardiology and European Atherosclerosis Society) task force recommends stronger action in this regard’, Prof Richard Hobbs, professor and head of Primary Care, University of Burmingham, UK, noted in his countrywide talks to South African doctors, sponsored by Ast...

affinity based target deconvolution of safranal

Advances in brachytherapy: new approaches to target breast cancer.

Advances in breast brachytherapy techniques have led to the development of new approaches for treatment of patients with early-stage breast cancer. This article reviews the indications, clinical utility, and nursing interventions for the Mammosite Radiation Therapy System (Proxima Therapeutics, Alpharetta, GA) and INTRABEAM (Photoelectron Corporation, North Billerica, MA) radiation therapy syst...